The African Society of Human Genetics was established in 2003 with the central goal of building capacity of the African scientific community and policymakers to contribute to the field of genetics research and to attract global attention to African genomic research and researchers. Almost two decades later, the AfSHG members have contributed to the expansion of the Genomic Research field in Africa. This workshop will introduce participants to African Genetic Diversity through webinars from a select number of AfSHG members (please note, the webinars will be open to the public). These talks will be solidified by background lectures, some case studies and hands-on tutorial sessions to introduce and highlight some key areas of research and provide some practical examples/exercises for participants to work on.
Overall Learning Outcomes
This module will provide graduates with the core theoretical foundations and technical skills necessary to carry out African genomics research. The uniqueness about this course is led by members of the African Society of Human Genetics (AfSHG).
||Approximately 3 days|
An introductory talk. This will outline how the webinar, practicals and background are linked.
These are lunchtime webinars which will be open to the public (These will be live) This will be delivered by senior researchers from the African Society of Human Genetics who have a track record in their area. The webinars will be open to everyone and widely distributed by both stakeholders. The webinars will be prerecorded and the presenters will only be present to answer questions
These will give background to the material for the day. This lecture explain how the webinar, the case studies and the practical sessions are linked (these will be pre-recorded).
|30 - Background|
|Case studies||Researchers working on African populations will present their work (these will be pre-recorded)||30 mins|
|Day||Module description||Webinar (Online)||Background (This will be given by 3 researchers who will travel to Ireland)||Case studies (30 mins)||Practical Session|
|1||This session aims to introduce participants to the African genomes and highlights the need to discover new disease gene associations in these populations through case studies.||Ambroise Wonkam:
|Title: History and architecture of the African Genomes, principle of population structure/admixture and Gene Discovery
Lecturer: Valentina Ngo Bitoungui & Emile Chimusa, Tinashe Chikowore Learning Outcomes:
Topic: Disease-gene associations
Samuel Adadey: Hearing Loss African Specific Variants: From Detection to Policy
Valentina Ngo Bitoungui: Kidney Dysfunction of Sickle Cell Disease
|Topic: Novel gene identification using NGS|
|2||Cross-population applicability of genomics results and the design of a genotyping array for African populations||Ananyo Choudhury
Development of the H3Africa Chip 15 November
|Title: Computational Population Genomics and Applicability of Genomic Tools on African Populations.
Lecturer: Emile Chimusa
Topic: Evolutionary history of sickle-cell mutation: implications for global genetic medicine-Kevin Kum Esoh Ghada Kamah: Medical Genetic Services
|Topic:Genome-wide association studies for African populations. South African TB populations.
Tutors: Tinashe Chikowore & Emile Chimusa
|3||Opportunities – why African genomic diversity is important||Segun Fatumo Complex disease-gene associations 16 November||Title: Introduction to Polygenic risk scores methods and tools/ transferability
Lecturer: Tinashe Chikowore and Emile Chimusa
|Leon Mutesa/Clarisse Musanabaganwa
Topic: Epigenetics and Trauma
Michele Ramsay: AWIGEN Study
Topic: ??? Dr Amadou Gaye
|Topic: Polygenic risk scores
Tutors: Tinashe Chikowore & Emile Chimusa
Learning outcomes: How to calculate polygenic risk scores
|4||Infectious disease genomics on the African continent||Webinar: Professor Chris Happi
Background: Evolutionary Analyses of Infectious Diseases in Africa
Lecturer: Richard Daodu, Tinashe
Topic: Human-Tuberculosis Co-evolution in African Populations:
Topic: Malaria Genomics in Africa
Topic: HIV epidemiology and molecular evolution
Topic: Vaccine design for Infectious diseases Tutors:, Ireland?
Topic: Dataset - Richard
|5||Project proposals and ethics||
Webinar: Dr Nchangwi Syntia Munung
Topic: Ethical, legal and social implications in Genomics Research in Africa
Lecturer: Cathal Seoighe
|Case studies: Young Investigators’ Forum
Group proposal writing & submission after 2 weeks.